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- Refrigerants
- Second-generation
- Third-generation
- Blended refrigerant
- Fourth-generation
- UV Series
- UV absorber
- Light stabilizers
- Melanin



Shandong Do Sender Chemicals Co.,Ltd.
- Refrigerants
- Second-generation
- Third-generation
- Blended refrigerant
- Fourth-generation
- UV Series
- UV absorber
- Light stabilizers
- Melanin
- …
- Refrigerants
- Second-generation
- Third-generation
- Blended refrigerant
- Fourth-generation
- UV Series
- UV absorber
- Light stabilizers
- Melanin

HFC-125/R125
Pentafluoroethane (R125)
CAS No.: 354-33-6 UN No.: 3220 CLASS No.: 2.2 Molecular formula: C₂HF₅
It is mainly used as a refrigerant .

R125
R125 (Pentafluoroethane), identified by CAS No. 354-33-6, is a hydrofluorocarbon (HFC) refrigerant with excellent thermodynamic properties. It is a colorless gas with a faint ethereal odor, commonly used as a component in refrigerant blends due to its non-flammability and zero ozone depletion potential (ODP).
Applications
Refrigerant Blends
Essential non-flammable component in R410A and R407 series blends, enabling their safe use in residential/mobile AC, heat pumps, and commercial refrigeration.
Fire Suppression
Key agent in clean fire suppression systems (e.g., FM-200).
System Integration
Used across the listed HVAC&R applications (AC, MAC, heat pumps, industrial refrigeration).
Transition Solution
Critical for retrofitting older CFC/HCFC systems.
Specialty Use
Serves as an aerosol propellant in niche applications.
Physical & Chemical Properties
Basic & Physical Properties
Molecular Weight: 120.02 g/mol
Boiling Point (1 atm): -48.1°C(-54.6°F)
Freezing Point: -103°C (-153°F)
Critical Temperature: 66.0°C(150.8°F)
Critical Pressure: 3.62 MPa (525 psia)
Liquid Density (25°C): ~1,200 kg/m³
Vapor Density (air=1): 4.1
Specific Heat (Liquid, 25°C): ~1.30 kJ/(kg·K)
Vapor Thermal Conductivity: Low
Environmental & Safety Properties
Flammability: Class A1 - Non-flammable (Key differentiator)
Flammability Limits: Non-flammable under all practical conditions
Auto-Ignition Temperature: Non-flammable
ODP (Ozone Depletion): 0
GWP (Global Warming): 3,170 (IPCC AR5) - Very High
Atmospheric Lifetime: ~29 years
Toxicity: Class A (Low toxicity; asphyxiant at high concentrations)
Thermodynamic & Application Profile
Primary Role: Fire suppression component in refrigerant blends. Its main value is being a non-flammable HFC with good thermodynamic properties.
Capacity & Efficiency: Lower volumetric cooling capacity than R143a or R32, but provides stability.
Glide: Used primarily in zeotropic blends.
Packaging, Storage & Transportation
Packaging Options
Cylinders: 10 kg, 20 kg, 50 kg disposable steel cylinders
ISO Tanks: Bulk transport in 20-24 MT ISO containers
Drums: 500 kg and 1000 kg returnable steel drums
Storage Guidelines
Storage Temperature: Below 52°C (125°F), preferably in cool, dry area
Ventilation: Well-ventilated area, away from ignition sources
Separation: Store away from oxidizing materials and combustible substances
Cylinder Position: Store upright with valve protection caps in place
Transportation
UN Identification Number: UN 3220 (Pentafluoroethane or Refrigerant gas R125)
Transport Hazard Class: Class 2.2 (Non-flammable, non-toxic gas)
Proper Shipping Name: PENTAFLUOROETHANE or REFRIGERANT GAS R125
FAQ
What is R125 (CAS No. 354-33-6) and what are its primary applications?
What is the chemical formula and molecular weight of R125?
What is the boiling point of R125 at atmospheric pressure?
Is R125 flammable? What is its ASHRAE safety classification?
What is the ozone depletion potential (ODP) of R125?
What is the global warming potential (GWP) of R125?
What are the key thermodynamic properties of R125?
What refrigerant blends contain R125 as a component?
How should R125 cylinders be stored safely?
What is the UN identification number for R125?
Can R125 be used as a standalone refrigerant?
What are the environmental regulations affecting R125 use?
What are suitable alternatives to R125-based blends?
What safety precautions are needed when handling R125?
What is the vapor pressure of R125 at 25°C?
What is the auto-ignition temperature of R125?
What are the compatibility considerations for R125 with materials?
What is the typical purity requirement for commercial R125?
How is R125 typically manufactured?
What are the recovery and recycling requirements for R125?
Refrigerants
Second Refrigerant
R22
Third Generation
R32
R23
HFC-143A
R134A
HFC-125
R152A
Blended Refrigerant
R404A
R407C
R410A
R507A
Fourth Generation
R1234YF
UV Series
UV absorber
UV-1164
BP-2
UV-1
UV-123
UV-327
UV-P
UV-329
UV-1130
Light satabilizers
UV-292
UV-770
Melanin
2-Anilino-6-(dibutylamino)-3-me
Other chemicals
2-Hydroxy-2methylpropiophenone
1,3-benzothiazol-2-ylsulfanylme
4-Chloro-3,5-dimethylphenol (CA
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Sales Office Address:No. 66, Zhongrun Avenue, Zhangdian District, Zibo City, Shandong Province,China.
Manufacture Facility: Fine Chemical Industry Park, Zhangdian District, Zibo City, Shandong Province,China.
