• Product Overview: 4-Chloro-3,5-dimethylphenol (CAS 88-04-0)

    4-Chloro-3,5-dimethylphenol (commonly known as Chloroxylenol or PCMX) is a broad-spectrum antimicrobial agent belonging to the halophenol class. It appears as a white to off-white crystalline powder with a characteristic phenolic odor . It is the active ingredient in antiseptic formulations like Dettol and is included in the WHO Model List of Essential Medicines . PCMX is effective against a wide range of Gram-positive and Gram-negative bacteria, fungi, and molds, making it one of the most widely used antiseptics in pharmaceutical, personal care, and industrial applications

    Appearance (23°C) White to off-white crystalline powder

    Purity (HPLC/GC) ≥98.0% – ≥99.0%

    Melting Point 114-116°C

    Boiling Point 246°C/1013 hPa

    Flash Point 132°C (closed cup)

    Density 0.67 g/cm³

    pH (0.2 g/L in H₂O) 7

    ]Water Solubility (20°C) 0.3 g/L

    Molecular Weight 156.61 g/mol

    Solubility & Compatibility Profile

    Parameter Details

    IUPAC Name 4-chloro-3,5-dimethylphenol

    Synonyms Chloroxylenol, PCMX, p-Chloro-m-xylenol, 2-Chloro-

    m-xylenol,Benzytol,Ottasept, Desson, Espadol

    EINECS/EC Number 201-793-8

    MDL Number MFCD00002324

    PubChem CID2723

    InChI Key OSDLLIBGSJNGJE-UHFFFAOYSA-N

    SMILES CC1=CC(=CC(=C1Cl)C)O

    RTECS Number ZE6850000

    UNII0F 32U78V2Q

  • Performance Advantages

    Broad-Spectrum Activity: Effective against Gram-positive, Gram-negative bacteria, fungi, and molds
    Low Toxicity Profile: Oral LD50 (rat) 3830 mg/kg; safe for topical use in approved concentrations
    Chemical Stability: Excellent stability under normal storage conditions; does not lose activity
    Regulatory Acceptance: FDA-approved, listed in pharmacopeias, and WHO Essential Medicines list
    Versatile Solubility: Freely soluble in organic solvents (alcohols, ethers, glycols) and alkali hydroxide solutions
    Chloroxylenol (PCMX) is a versatile antimicrobial with applications spanning pharmaceuticals, personal care, industrial preservation, and healthcare :
    Antiseptic handwashes (0.1-1.5%
    Surgical scrubs & healthcare products
    First aid sprays / wound cleansers
    Antibacterial soaps & liquid detergents
    Dandruff control shampoos
    Disinfectant formulations (4.5-5%)
    Industrial preservatives (glues, paints)
    Textile & pulp preservation
    Pharmaceutical intermediates
    Veterinary antiseptic products

    Personal Care & Cosmetics

    PCMX is extensively used in personal care products at concentrations of 0.5-1.0% in liquid detergents, 1.0% in antibacterial hand cleansers, and 4.5-5.0% in disinfectant formulations . It is approved by FDA for use in antiseptic hand cleansers and soaps .

    Pharmaceutical & Healthcare

    As an active pharmaceutical ingredient, chloroxylenol is indicated for topical application on cuts, bites, stings, and abrasions, and as an antiseptic hand cleaner [citation:8]. It is the primary antimicrobial in Dettol and similar first-aid antiseptic products. The WHO includes it in the Model List of Essential Medicines .

    Industrial Preservation

    Beyond healthcare, PCMX serves as an effective preservative in glues, paints, textile processing, and pulp manufacturing, protecting against microbial degradation during storage and application.

    Standard Packaging

    Laboratory R&D: 100 g, 500 g, 1 kg plastic bottles
    Industrial drums: 25 kg fiber drum with PE liner (typical)
    Bulk quantities: 200 kg drums, IBC totes, custom packaging available

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